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xylocaine visqueuse 2

 
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rebeshko



: +14    

: 08.11.12
: 13
: Kiev

9.04.2014 03:28   ³

Pharmacokinetics of xylocaine
After receiving xylocaine in the middle xylocaine is well absorbed is absorbed from the gastrointestinal tract (average 85%). Cmax achieved through 6 h Reception immediately before food low fat does not affect the pharmacokinetic rules xylocaine.
The "first pass " through the liver xylocaine biotransformed to form active beta - metabolites. Plasma protein binding is 95%.
Concentration active xylocaine metabolite in human systemic circulation is less than 5 %.
Excreted unchanged group and group metabolites , mainly in the bile - 60-85 %, 10-15% - in the form of passive deleted kidneys.


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