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: 08.11.12
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10.04.2014 09:32   ³

Pharmacokinetics of xylocaine
After receiving xylocaine inside xylocaine is well absorbed is absorbed from the gastrointestinal tract (average 85%). Cmax achieved through 6 h Reception immediately before food low fat does not affect the pharmacokinetic rules xylocaine.
The "first pass " through the liver xylocaine biotransformed to form active beta - metabolites. Plasma protein binding is 95%.
Concentration energetic xylocaine metabolite in human systemic circulation is less than 5 %.
Excreted unchanged image and a metabolites , mainly in the bile - 60-85 %, 10-15% - in the form of inactive deleted kidneys.

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